Your Brain on Loneliness

A deep dive into the neuroscience of loneliness, how social isolation impairs brain function, and what we can do to recover.

Stephan Joppich
13 min readAug 20, 2023
Image created on Canva.

Kaboom!

Before the young man could realize what he’d done, a tamping rod half his size blasted through his left cheek, exited the top of his skull, and landed a train car’s length away from him.

The year was 1848. The place was a railway construction site in Vermont. The man was Phineas Gage.

What happened next would forever change our understanding of the human brain. Immediately after the explosion, Gage acted like the clean-cut hole in his skull was just a scratch. He walked toward the nearest cart, drove into town, and saw a doctor. And as if this wasn’t enough, he joked about his injury.

“Here,” Gage told the doctor, “is enough business for you,”

Gage recovered miraculously — without speech, motor, or memory impairments. But something had changed. In the aftermath of the injury, the once clever, conscientious, reasonable young man became stubborn, unreliable, and disrespectful. His colleagues later remarked he was “no longer Gage.”

This may seem like an extreme, outdated case. But in today’s age of loneliness, many of us (myself included)…

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Stephan Joppich

Engineer turned philosophy student • I write about loneliness, transformative books, and other pseudo-deep stuff that keeps me up at night • stephanjoppich.com